Peter Doshi este redactor senior la The BMJ (British Medical Journal)<\/span><\/a> \u0219i \u00een echipa News & Views. Cu sediul \u00een Baltimore, el este, de asemenea, profesor asociat de cercetare \u00een domeniul serviciilor de s\u0103n\u0103tate farmaceutic\u0103 la University of Maryland School of Pharmacy<\/span><\/a>. Cercetarea sa se concentreaz\u0103 asupra procesului de aprobare a medicamentelor, asupra modului \u00een care riscurile \u0219i beneficiile produselor medicale sunt evaluate \u0219i comunicate \u0219i \u00eembun\u0103t\u0103\u021birea credibilit\u0103\u021bii \u0219i acurate\u021bei sintezei dovezilor \u0219i a publica\u021biilor biomedicale. Doshi militeaz\u0103 pentru o mai mare transparen\u021b\u0103 a datelor din studiile clinice \u0219i conduce ini\u021biativa Restoring Invisible and Abandoned Trials (RIAT), care \u00ee\u0219i propune s\u0103 se asigure c\u0103 publica\u021biile din studiile clinice sunt corecte, complete \u0219i datele sunt disponibile publicului. Doshi are, de asemenea, interese puternice \u00een jurnalism ca vehicul pentru \u00eencurajarea practicilor mai bune \u0219i \u00eembun\u0103t\u0103\u021birea \u00eentreprinderii de cercetare. Doshi a absolvit o burs\u0103 \u00een cercetarea eficien\u021bei comparative la Johns Hopkins \u0219i \u0219i-a luat doctoratul \u00een istorie, antropologie \u0219i \u0219tiin\u021b\u0103, tehnologie \u0219i societate de la Institutul de Tehnologie din Massachusetts, una din cele mai prestigioase institu\u021bii de \u00eenv\u0103\u021b\u0103m\u00e2nt din lume.<\/span><\/p>\n Mai multe informa\u021bii despre Peter Doshi ve\u021bi putea afla dac\u0103 accesa\u021bi acest link: https:\/\/www.bmj.com\/about-bmj\/editorial-staff\/peter-doshi<\/span><\/a>`<\/span><\/p>\n Mai multe informa\u021bii despre The British Medical Journal pute\u021bi g\u0103si aici: https:\/\/en.wikipedia.org\/wiki\/The_BMJ<\/span><\/a><\/span><\/p>\n Nu a\u021bi \u0219tiut p\u00e2n\u0103 acum despre existen\u021b\u0103 acestui om? <\/span><\/p>\n Ciudat, pentru c\u0103 vorbim despre o celebritate. <\/span><\/p>\n Dar poate nu \u0219ti\u021bi nimic despre el pentru c\u0103 oresa rom\u00e2neasc\u0103 evite s\u0103 abordeze acest subiect. <\/span><\/p>\n Stric\u0103 la afaceri.<\/span><\/p>\n \n \n \n Mai jos ve\u021bi putea vedea dou\u0103 declara\u021bii ale lui Peter Doshi.<\/span><\/p>\n Dup\u0103 fiecare declara\u021bie ve\u021bi putea citi transcriptul declara\u021biei \u00een limba englez\u0103 iar \u00een final, p<\/span>entru c\u0103 toat\u0103 lumea s\u0103 \u00een\u021beleag\u0103 despre ce este vorba, ve\u021bi putea citi o traducere \u00een limba rom\u00e2n\u0103, \u00een traducere Google Translate.<\/span><\/p>\n At\u00e2t transcripturile \u00een englez\u0103 c\u00e2t \u0219i traducerile \u00een rom\u00e2n\u0103 s-ar putea s\u0103 nu fie perfecte, \u00een fond sunt texte generate de un robot, dar sunt destul de bune pentru ca oricine s\u0103 \u00een\u021beleag\u0103 ce se afirm\u0103 \u00een declara\u021biile respective.<\/span><\/p>\n In rest, nu trebuie dec\u00e2t s\u0103 v\u0103 folosi\u021bi creierele \u0219i s\u0103 g\u00e2ndi\u021bi. <\/span><\/p>\n Acest lucru este \u00eenc\u0103 legal.<\/span><\/p>\n \n \n \n Transcriptul declara\u021biei \u00een limba englez\u0103<\/span><\/strong><\/p>\n Hello, I\u2019m Peter Doshi. For identification purposes, I\u2019m on the faculty of the University of Maryland and editor of the BMJ. I have no relevant conflicts of interest and my comments today are my own. In pharmacy school I teach a required course on how to critically appraise the medical literature. We train students on how to go beyond a study abstract and start to pick apart and critically assess biomedical studies, not just take them at face value. I want to use my five minutes here to harness that spirit of critical thinking. I\u2019m saddened that we are super-saturated as a society right now in the attitude of \u201ceverybody knows\u201d that has shut down intellectual curiosity and leads to self-censorship. <\/span><\/p>\n \u2018So let me start with a few \u201ceverybody knows\u201d examples that I\u2019m not sure we should be so certain about. Everybody knows that this is a pandemic of the unvaccinated. But if hospitalisations and deaths were almost exclusively occurring in the unvaccinated, why would booster shots be necessary? Or why would the statistics be so different in the UK, where most Covid hospitalisations and deaths are among the fully vaccinated, as Senator Johnson said? There\u2019s a disconnect there, there\u2019s something to be curious about. There\u2019s something not adding up and we should all be asking: \u201cIs it\u2019s true that this is a pandemic of the unvaccinated? What does that even mean?\u201d (Next slide please). <\/span><\/p>\n \u2018And then there\u2019s this: Everybody knows that Covid vaccines save lives, in fact we\u2019ve known this from early 2021. The clinical trials proved that to be the case, as you can see here [in the quote of a February article in the Journal of the American Medical Association]. But is it true? When that statement by prominent public health officials was penned, there had been just one death, one death across the 70,000 Pfizer and Moderna trial participants. Today, we have more data, and you can see that there were similar numbers of deaths in the vaccine and placebo groups. <\/span><\/p>\n The trials did not show a reduction in death. Even for Covid deaths, as opposed to other causes, the evidence is flimsy, with just two deaths in the placebo group versus one in the vaccine group. My point is not that I know the truth about what the vaccine can and cannot do, my point is that those who claimed the trials showed the vaccines were highly effective in saving lives were wrong. The trials did not demonstrate this. (Next slide please).<\/span><\/p>\n \u2018Now let\u2019s talk about anti-vaxxers. Everybody knows you should discount what anti-vaxxers have to say. But what does the term mean? The Merriam-Webster dictionary defines it as, quote, \u201ca person who opposes use of vaccines or regulations mandating vaccination\u201d. The first part of the definition I expected, the second part stunned me. There are entire countries from the United Kingdom to Japan which do not mandate childhood vaccines. Both achieve high levels of vaccination, just not through regulations mandating vaccines. There are no mandates there and I would wager that a large minority, perhaps a majority, of the world\u2019s population meets the definition here of an anti-vaxxer. Another definition worth checking is \u201cvaccine\u201d. (Next slide please). <\/span><\/p>\n \u2018I am one of the academics that argues that these mRNA products, which everybody calls vaccines, are qualitatively different than standard vaccines. And so I found it fascinating to learn that Merriam-Webster changed its definition of \u201cvaccine\u201d early this year. mRNA products did not meet the definition of \u201cvaccine\u201d that has been in place for 15 years in Merriam-Webster, but the definition was expanded such that mRNA products are now vaccines. I highlight this to ask a question: How would you feel about mandating COVID vaccines if we didn\u2019t call them vaccines? What if these injections were called \u201cdrugs\u201d instead? So here\u2019s the scenario: We have this \u201cdrug\u201d, and we have evidence that it doesn\u2019t prevent infection, nor does it stop viral transmission, but the \u201cdrug\u201d is understood to reduce your risk of getting very sick and dying of COVID. Would you take a dose of this drug every six months or so for possibly the rest of your life? If that\u2019s what it took for the drug to stay effective? Would you not just take this drug yourself, but support regulations mandating that everybody else around you take this drug? Or would you say, \u201cHold on a sec\u201d. Maybe you\u2019d say that, \u201cIf that\u2019s all the drug does, why not use a normal medicine instead? The kind we take when we\u2019re sick and want to get better? And why would you mandate it?\u201d <\/span><\/p>\n \u2018The point is, just because we call it a vaccine doesn\u2019t mean we should assume these new products are just like all other childhood vaccines which get mandated. Each product is a different product, and if people are okay with getting something simply because \u201cit\u2019s a vaccine and we mandate other vaccines, so why shouldn\u2019t we mandate this?\u201d, I think it\u2019s time to inject some critical thinking into that conversation and that is what I hope we are doing today.\u2019<\/span><\/p>\n \n \n Transcriptul declara\u021biei tradus \u00een limba rom\u00e2n\u0103 \u2013 traducere Google Translate<\/span><\/strong><\/p>\n Bun\u0103, sunt Peter Doshi. \u00cen scopuri de identificare, sunt la facultatea Universit\u0103\u021bii din Maryland \u0219i editor al BMJ. Nu am conflicte de interese relevante \u0219i comentariile mele de ast\u0103zi sunt ale mele. La \u0219coala de farmacie predau un curs obligatoriu despre cum s\u0103 evaluez critic literatura medical\u0103. Antren\u0103m studen\u021bii despre cum s\u0103 dep\u0103\u0219easc\u0103 un rezumat de studiu \u0219i s\u0103 \u00eencepem s\u0103 dep\u0103rt\u0103m \u0219i s\u0103 evalu\u0103m critic studiile biomedicale, nu doar s\u0103 le lu\u0103m la valoarea nominal\u0103. Vreau s\u0103-mi folosesc cele cinci minute aici pentru a valorifica acel spirit de g\u00e2ndire critic\u0103. Sunt \u00eentristat c\u0103 suntem supra-satura\u021bi ca societate \u00een acest moment \u00een atitudinea \u201etoat\u0103 lumea \u0219tie\u201d care a oprit curiozitatea intelectual\u0103 \u0219i duce la autocenzur\u0103.<\/span><\/p>\n \u201eA\u0219a c\u0103 permite\u021bi-mi s\u0103 \u00eencep cu c\u00e2teva exemple de \u201etoat\u0103 lumea \u0219tie\u201d de care nu sunt sigur c\u0103 ar trebui s\u0103 fim at\u00e2t de siguri. Toat\u0103 lumea \u0219tie c\u0103 aceasta este o pandemie a celor nevaccina\u021bi. Dar dac\u0103 spitaliz\u0103rile \u0219i decesele au avut loc aproape exclusiv la cei nevaccina\u021bi, de ce ar fi necesare vaccinuri de rapel? Sau de ce ar fi statisticile at\u00e2t de diferite \u00een Marea Britanie, unde majoritatea spitaliz\u0103rilor \u0219i deceselor de Covid se num\u0103r\u0103 printre cei complet vaccina\u021bi, a\u0219a cum a spus senatorul Johnson? Exist\u0103 o deconectare acolo, exist\u0103 ceva de care s\u0103 fii curios. Exist\u0103 ceva care nu se \u00eencadreaz\u0103 \u0219i ar trebui s\u0103 ne \u00eentreb\u0103m cu to\u021bii: \u201eEste adev\u0103rat c\u0103 aceasta este o pandemie a celor nevaccina\u021bi? Ce inseamna asta?” (Urm\u0103torul slide v\u0103 rog).<\/span><\/p>\n \u201e\u0218i apoi mai este urm\u0103torul lucru: toat\u0103 lumea \u0219tie c\u0103 vaccinurile Covid salveaz\u0103 vie\u021bi, de fapt, \u0219tim acest lucru de la \u00eenceputul anului 2021. Studiile clinice au demonstrat c\u0103 este cazul, a\u0219a cum pute\u021bi vedea aici [\u00een citatul unui articol din februarie \u00een Jurnalul Asocia\u021biei Medicale Americane]. Dar este adev\u0103rat? C\u00e2nd a fost scris\u0103 aceast\u0103 declara\u021bie a oficialilor de s\u0103n\u0103tate public\u0103 proeminen\u021bi, a existat doar un deces, un deces la cei 70.000 de participan\u021bi la studiile Pfizer \u0219i Moderna. Ast\u0103zi, avem mai multe date \u0219i pute\u021bi vedea c\u0103 au existat un num\u0103r similar de decese \u00een grupurile cu vaccin \u0219i placebo.<\/span><\/p>\n Studiile nu au ar\u0103tat o reducere a decesului. Chiar \u0219i pentru decesele cauzate de Covid, spre deosebire de alte cauze, dovezile sunt slabe, cu doar dou\u0103 decese \u00een grupul placebo fa\u021b\u0103 de unul \u00een grupul vaccin. Ideea mea nu este c\u0103 \u0219tiu adev\u0103rul despre ceea ce poate \u0219i ce nu poate face vaccinul, ideea mea este c\u0103 cei care au sus\u021binut c\u0103 studiile au ar\u0103tat c\u0103 vaccinurile sunt extrem de eficiente \u00een salvarea de vie\u021bi au gre\u0219it. Procesele nu au demonstrat acest lucru. (Urm\u0103torul slide v\u0103 rog).<\/span><\/p>\n \u201eAcum s\u0103 vorbim despre anti-vaxxeri. Toat\u0103 lumea \u0219tie c\u0103 ar trebui s\u0103 renun\u021bi la ceea ce au de spus anti-vaxxenii. Dar ce \u00eenseamn\u0103 termenul? Dic\u021bionarul Merriam-Webster \u00eel define\u0219te ca, citat, \u201eo persoan\u0103 care se opune utiliz\u0103rii vaccinurilor sau reglement\u0103rilor care impun vaccinarea\u201d. Prima parte a defini\u021biei m\u0103 a\u0219teptam, a doua parte m-a uimit. Exist\u0103 \u021b\u0103ri \u00eentregi, din Regatul Unit p\u00e2n\u0103 \u00een Japonia, care nu impun vaccinuri pentru copil\u0103rie. Ambele ating niveluri ridicate de vaccinare, doar nu prin reglement\u0103ri care impun vaccinuri. Nu exist\u0103 mandate acolo \u0219i a\u0219 paria c\u0103 o mare minoritate, poate o majoritate, a popula\u021biei lumii \u00eendepline\u0219te defini\u021bia de aici a unui anti-vaxx. O alt\u0103 defini\u021bie care merit\u0103 verificat\u0103 este \u201evaccin\u201d. (Urm\u0103torul slide v\u0103 rog).<\/span><\/p>\n \u201eSunt unul dintre academicienii care sus\u021bin c\u0103 aceste produse ARNm, pe care toat\u0103 lumea le nume\u0219te vaccinuri, sunt calitativ diferite de vaccinurile standard. \u0218i a\u0219a mi s-a p\u0103rut fascinant s\u0103 aflu c\u0103 Merriam-Webster \u0219i-a schimbat defini\u021bia \u201evaccinului\u201d la \u00eenceputul acestui an. Produsele ARNm nu au \u00eendeplinit defini\u021bia \u201evaccinului\u201d care a fost \u00een vigoare de 15 ani \u00een Merriam-Webster, dar defini\u021bia a fost extins\u0103 astfel \u00eenc\u00e2t produsele ARNm sunt acum vaccinuri. Eviden\u021biez acest lucru pentru a pune o \u00eentrebare: cum v-a\u021bi sim\u021bi despre obligarea vaccinurilor COVID dac\u0103 nu le-am numi vaccinuri? Ce se \u00eent\u00e2mpl\u0103 dac\u0103 aceste injec\u021bii s-ar numi \u00een schimb \u201edroguri\u201d? Deci, iat\u0103 scenariul: avem acest \u201emedicament\u201d \u0219i avem dovezi c\u0103 nu previne infec\u021bia \u0219i nici nu opre\u0219te transmiterea viral\u0103, dar se \u00een\u021belege c\u0103 \u201emedicamentul\u201d reduce riscul de a te \u00eemboln\u0103vi grav \u0219i de a muri de COVID . A\u021bi lua o doz\u0103 din acest medicament la fiecare \u0219ase luni sau cam a\u0219a ceva, eventual, pentru tot restul vie\u021bii? Dac\u0103 asta a fost necesar pentru ca medicamentul s\u0103 r\u0103m\u00e2n\u0103 eficient? Nu a\u021bi lua acest medicament doar dvs., ci a\u021bi sprijini reglement\u0103rile care impun ca to\u021bi ceilal\u021bi din jurul vostru s\u0103 ia acest medicament? Sau ai spune: \u201eA\u0219teapt\u0103 o secund\u0103\u201d. Poate a\u021bi spune c\u0103, \u201eDac\u0103 asta este tot ce face medicamentul, de ce s\u0103 nu folosi\u021bi un medicament normal \u00een schimb? Genul pe care \u00eel lu\u0103m atunci c\u00e2nd suntem bolnavi \u0219i vrem s\u0103 ne \u00eembun\u0103t\u0103\u021bim? \u0218i de ce l-a\u021bi mandata?\u201d<\/span><\/p>\n \u201eIdeea este c\u0103 doar pentru c\u0103 \u00eel numim un vaccin nu \u00eenseamn\u0103 c\u0103 ar trebui s\u0103 presupunem c\u0103 aceste produse noi sunt la fel ca toate celelalte vaccinuri pentru copil\u0103rie care sunt obligatorii. Fiecare produs este un produs diferit \u0219i, dac\u0103 oamenii sunt de acord s\u0103 ob\u021bin\u0103 ceva pur \u0219i simplu pentru c\u0103 \u201eeste un vaccin \u0219i impunem alte vaccinuri, a\u0219a c\u0103 de ce nu ar trebui s\u0103 impunem acest lucru?\u201d, cred c\u0103 este timpul s\u0103 inject\u0103m o g\u00e2ndire critic\u0103 \u00een acea conversa\u021bie. \u0219i asta sper c\u0103 facem ast\u0103zi.<\/span><\/p>\n \n \n \n![\"Capture\"](\"https:\/\/infokam.eu\/blog\/wp-content\/uploads\/2021\/11\/Capture_thumb.jpg\" "\\"Capture\\"")
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